Magnetic silica microspheres have become increasingly imperative and popular for a variety of applications. They provide combined advantages of working with bead platform and the unique properties of a silica substrate, including: flexibility, large specific surface area, improved binding kinetics over plane surfaces, robust statics, flexible silanization chemistries, unique refractive index and density etc.
The dimension of the magnetic silica beads is the key factor for the successful magnetic separation. It is usually less than 10 nano meter to make sure perfect and selective interaction with biological objects. These particles surface are modified with biocompatible inorganic or else organic materials to both prevent aggregation caused by hydrophobic or else magnetic attraction as well as facilitate the immobilization of specific ligands such as antibody, aptamer, and DNA.
The magnetic microparticles have been attracted for use in bio application for numerous years, due to advantages that they provide easily scalable, time-efficient, cost-effective, and gentle separation of biological compounds by using external magnetic field incline.
The magnetic silica microspheres offered numerous exciting uses in biomedical field as a solid support for
· protein purification
· besieged drug delivery
· cell separation
· medical diagnosis
· immunoassays
· DNA sequencing
· and cell analysis
Various materials have been utilized for matrices embedding super paramagnetic nano particles in the form of micro beads. Despite wide-ranging efforts made by numerous research groups, the demand for magnetic polymeric particles having uniform size, chemical stability, user-defined magnetic contents, bio-compatibility, and the readily tailor able surface is still escalating in potential application to biochips as well as bio-separation.
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